Regulation of Innate Behaviors by Cell Ensembles in the Lateral Hypothalamus
The project will focus on investigation of connectivity, dynamics and function of hypothalamic circuits. It aims to identify involvement of cell groups in the lateral hypothalamus in a regulation of innate behaviors, including social behaviors, and to study various patterns of neural dynamics that may underlie these behaviors. These studies will gain insight into various functions of hypothalamic circuits and neuronal mechanisms of innate behaviors in health and pathology.
Methodology & Research Model
We apply a combination of the following methods in behaving transgenic mice: - optogenetics; - electrophysiological recordings of neuronal activity and neuronal network oscillations; - calcium imaging; - behavioral assays.
Requirements for Application
Optimism and curiosity. Experience in in vivo experiments and/or data analysis will be beneficial.
1. Carus-Cadavieco M, Gorbati M, Ye L, Bender F, van der Veldt S, Kosse C, Börgers C, Lee SY, Ramakrishnan C, Hu Y, Denisova N, Ramm F, Volitaki E, Burdakov D, Deisseroth K, Ponomarenko A, Korotkova T (2017). Gamma oscillations organize top-down signaling to hypothalamus and enable food seeking. Nature, 542(7640):232-236.
2. Herrera CG, Carus-Cadavieco M, Jego S, Ponomarenko A, Korotkova T, Adamantidis A (2016). Hypothalamic feed-forward inhibition of thalamocortical network controls arousal and consciousness. Nature Neuroscience, 19(2):290-8.
3. Bender F, Gorbati M, Carus-Cadavieco M, Denisova N, Gao X, Holman C, Korotkova T, Ponomarenko A (2015). Theta oscillations regulate speed of locomotion via hippocampus to lateral septum pathway. Nature Communications, 6:8521 doi: 10.1038/ncomms9521.
4. Korotkova T, Fuchs EC, Ponomarenko A, von Engelhardt J, Monyer H (2010). NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representation and working memory. Neuron, 68(3):557-69.