UNIVERSITY OF COLOGNE

Thesis title: Intersectional Targeting Reveals Heterogeneous Nature of Glp1r- and Lepr-expressing POMC-Neurons
TAC: Brüning/Kloppenburg, Thesis defence 22.01.2021

Publications
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT and Brüning JC.
Nature Neuroscience, 2021 Jul;24(7):913-929.

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.
Ruud J, Alber J, Tokarska A,  Engstöm Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC.
Cell Rep 2019 Jun 11; 27 (11): 3182

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Riessland M*, Kaczmarek A*, Schneider S*, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.
*These authors contributed equally to this work.
Am J Hum Genet. 2017 Feb 2;100(2):297-315.

Current position: Postdoctoral Researcher at Brüning lab, Max Planck Institute for Metabolism Research, Cologne

Thesis title: Segregation of function in a sensory-motor circuit is not predicated on sensory topology
TAC: Korsching/Hammerschmidt/Kononenko
Thesis defence 01.12.2023

Publikations:

Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish
Birdal G, D' Gama PP, Jurisch-Yaksi N, Korsching SI.
Chem Senses, 2023, Vol 48, bjad040, https://doi.org/10.1093/chemse/bjad040

Current position: Project Manager at Exzellenz Start-up Center GATEWAY, University of Cologne

Thesis title: Regulation of transitions between innate behaviours by the lateral hypothalamus and its cortical inputs
TAC: Korotkova/Brüning/Steculorum, Thesis defence 12.03.2021

Publications
The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions.
Chen C^*, Altafi M^*, Corbu M, Trenk A, Munkhof H, Weineck K, Bender F, Carus-Cadavieco M, Bakhareva A, Korotkova T, Ponomarenko A.
Nature Neurosci 2024 Mar 18. doi: 10.1038/s41593-024-01598-3. advanced online
*These authors contributed equally to this work.

Prefrontal-subthalamic pathway supports action selection in a spacial working memory task
Heikenfeld C, Mederos S, Chen C, Korotkova T, Schnitzler A, Ponomarenko A.
Sci Rep., 2020; 10: 10497.

Current position: Postdoctoral Researcher at Dan lab, Berkeley University, California

Thesis title: The role of the femoral chordotonal organ in motor control, interleg coordination, and leg kinematics in Drosophila melanogaster
TAC: Büschges/Ito/Wellmann, Thesis defence 10.09.2020

Publications
Location and arrangement of campaniform sensilla in Drosophila melanogaster
Dinges GF, Chockley AS, Bockemühl T, Ito K, Blanke A, Büschges A.
J Comp Neurol 2021 Mar; 529(4):905-925.

Statistic stability predicts the continuum of interleg coordination patterins in Drosophila
Szczecinski NC, Bockemühl T, Chockley AS, Büschges A.
J Exp Biol 2018 Nov 16; 221: jeb189142

Current position: Freelance Scientific Copy Editor

Thesis title: Representation of innate behaviors by the hypothalamus and the ventral tegmental area
TAC: Korotkova/Kloppenburg/Nawrot, Thesis defence 24.09.2021

Publications:

The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions.
Chen C^*, Altafi M^*, Corbu M, Trenk A, Munkhof H, Weineck K, Bender F, Carus-Cadavieco M, Bakhareva A, Korotkova T, Ponomarenko A.
Nature Neurosci 2024 Mar 18. doi: 10.1038/s41593-024-01598-3. advanced online
*These authors contributed equally to this work.

Current position: Regulatory Manager at Procter&Gamble in Brüssel

Thesis title: Regulation of feeding by glucagon-like peptide-1 (GLP-1) receptor-expressing cells in the lateral hypothalamus

TAC Korotkova/Brüning/Steculorum

Thesis title: Amine detection in aquatic organisms: receptor evolution, neuronal circuits and behavior in the model organism zebrafish
TAC: Korsching/Kloppenburg/Manzini, Thesis defence 11.12.2017

Publications
Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
Dieris M, Kowatschew D, Korsching SI.
Sci Rep. 2021 Apr; 8;11(1):7807.

A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.
Dieris M, Ahuja G, Krishna V, Korsching S.
Sci Rep, 2017; 7: 40892

Current position: Application Specialist for Genomics & Liquid Handling, Beckman Coulter Life Sciences, Krefeld

Thesis title: Morphology of Leg Campaniform Sensilla and Their Role in Drosophila melanogaster Walking
TAC: Büschges/Ito/Zill, Thesis defence 22.07.2021

Publications
Ultra high-resolution biomechanics suggest that substructures within insect mechanosensors decisively affect their sensitivity
Dinges GF, Bockemühl T, Iacoviello F, Shearing PR, Büschges A, Blanke A.
J R Soc Interface, 2022; May; 19(190): 20220102

Location and arrangement of campaniform sensilla in Drosophila melanogaster
Dinges GF, Chockley AS, Bockemühl T, Ito K, Blanke A, Büschges A.
J Comp Neurol 2021 Mar;529(4):905.

Gradients in mechanotransduction of force and body weight in insects
Harris CM, Dinges GF, Haberkorn A, Gebehart C, Büschges A, Zill S.
Arthropod Stuct Dev, Sept 2020; 58 100970

Current position: Postdoctoral Researcher at West Virginia University, USA

Research associate
Research project: Role of Autophagy in Preventing Synaptic Dysfunctions in Distal Axonopathies
Advisors: Kononenko/Rugarli/Zempel

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, Ickert L, Mohammadi M, De Bruyckere E, Kallergi E, Delle Vode A, Nikoletopoulou V, Wirth B, Isensee J, Hucho T, Puchkov D, Isbrandt D, Krueger M, Kloppenburg P, Kononenko NL.
EMBO J. 2022, Oct 11;e110963.

Thesis title: Multimodal Proprioceptive Integration in Sensorimotor Networks of an Insect Leg
TAC: Büschges/Daun/El Manira, Thesis defence 17.09.2021

Publications

The processing of proprioceptive signals in distributed networks: insights from insect motor control
Gebehart C, Büschges A.
J Exp Biol, 2024, Jan 1;227(1):jeb246182. doi: 10.1242/jeb.246182
REVIEW
Related content: ECR Spotllight Corinna Gebehart:
J Exp Biol (2024) 227 (1): jeb247066.

Non-linear multimodal integration in a distributed premotor network controls proprioceptive reflex gain in the insect leg.
Gebehart C, Hooper S, Büschges A.
Current Biol. 2022, Vol 32, Issue 17, Sept 12, p. 3847

Temporal differences between load and movement signal integration in the sensorimotor network of an insect leg.
Gebehart C, Büschges A.
J Neurophysiol. 2021 Dec; 1;126(6):1875-18903.

Distributed processing of load and movement feedback in the premotor network controlling an insect leg joint
Gebehart C, Schmidt J, Büschges A.
J Neurophysiol. 2021 May; 1;125(5):1800-1813.

Gradients in mechanotransduction of force and body weight in insects
Harris CM, Dinges GF, Haberkorn A, Gebehart C, Büschges A, Zill S.
Arthropod Stuct Dev, Sept 2020; 58 100970
 

Current position: Postdoctoral Researcher at Chiappe Lab, Champalimaud Research Center, Lisbon

Thesis title: The Spatial Evolution of Tau Pathology in Alzheimer’s Disease: Influence of Functional Connectivity and Education
TAC: Drzezga/Fink/Daun, Thesis defence 11.12.2019

Publications
Level of education mitigates the impact of tau pathology on neuronal function.
Hönig MC, Bischof GN, Onur ÖA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T, Alzheimer's Disease Neuroimaging Initiative.
Eur J Nucl Med Mol Imaging. 2019 Aug; 46 (9):1787

Networks auf tau distribution in Alzheimer's disease.
Hönig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur ÖA, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A.
Brain, awx353, https://doi.org/10.1093/brain/awx353.

Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control.
Hammes J, Theis H, Giehl K, Hönig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T.
Brain 2019 Mar 1; 142 (3): 733

Tau pathology and cognitive reserve in Alzheimer's disease.
Hönig MC, Bischof GN, Hammes J, Faber J, Fliessbach K, van Eimeren T, Drzezga A.
Neuro Biol Aging, 2017; 57: 1

Current position: Postdoctoral Researcher at Multimodal Imaging Group, Research Centre Jülich and University Clinics Cologne

Thesis title: Anatomical and functional investigation of neuronal heterogeneity in the ventromedial hypothalamic nucleus
TAC: Brüning/Kloppenburg/Kurian, Thesis defence 02.08.2018

Current position: Postdoctoral Researcher at The Ohio State University Wexner Medical Center

Thesis title: Different Subsets of Serotonergic Neurons Regulate Carbohydrate and Protein Intake and are Modulated by Insulin-like Signaling in Drosophila melanogaster
TAC: Scholz/Rugarli/Hammerschmidt, Thesis defence 29.04.2019

Publications
The CApillary FEeder Assay Measures Food Intake in Drosophila melanogaster.
Diegelmann S, Jansen A, Jois S, Kastenholz K, Velo Escarcena L, Strudthoff N, Scholz H.
J Vis Exp, 2017 Mar 17; 121

Current position: Associate Underwriter at Gen Re, Cologne

Thesis Title: Unravelling the role of neuropeptides in insect motor control: from identification and localization to function.
TAC: Büschges/Predel/Kononenko, Thesis defence 20.05.2020

Publications
Neuromodulation can be simple: myoinhibitory peptide, contained in dedicated regulatory pathways, is the only neurally-mediated peptide modulator of the stick insect leg muscle
Liessem S, Kowatschew D, Dippel S, Blanke A, Korsching S, Guschlbauer C, Hooper SL, Predel R, Büschges A.
J Neurosci. 2021 Feb 2; JN-RM-0188-20.

Transcriptomic, peptidomic, and mass spectrometry imaging analysis of the brain in the ant Cataglyphis nodus
Habenstein J, Schmitt F,  Liessem S, Ly A, Trede D, Wegener C, Predel R, Rössler W, Neupert S.
J Neurochem, 2021 Jul; 158(2):391-412

Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass Spectrometry Imaging Protocol
Ly A, Ragionieri L, Liessem S,  Becker M, Deininger SO, Neupert S, Predel R.
Anal Chem 2019 Feb 5; 91 (3): 1980

Transcriptomic and Neuropeptidomic Analysis of the Stick Insect, Carausius morosus.
Liessem S, Ragioneri L, Neupert S, Büschges A, Predel  R.
J Proteome Res 2018, Jun 1; 17(6): 2192

Current position: Postdoctoral Researcher at Ache Lab, Julius-Maximillians-University Würzburg

Thesis Title: Effects of aging on human motor network connectivity
TAC: Daun/Fink/Wellmann, Thesis defence 28.11.2018

Publications
Aging-associated changes of moving-related functional connectivity in the human brain.
Rosjat N, Liu L, Wang BA, Popovych S, Toth T, Viswanathan S, Grefkes C, Fink GR, Daun S.
Neuropsychologia. 2018 Jul 9; S0028-3932(18)30306-3.

Age-related changes in oscillatory power affect motor action.
Liu L, Rosjat N, Popovych S, Wang BA, Yeldesbay A, Thot TI, Viswanathan S, Grefkes CB, Fink GR, Daun S.
PLoS One, 2017; 12 (11):e0187911.

Movement-related phase locking in the delta-theta frequency band.
Popovych S, Rosjat N, Toth TI, Wang BA, Liu L, Abdollahi RO, Viswanathan S, Grefkes C, Fink, GR, Daun S.
Neuroimage, 2016 Jun 29;139:439-449.
 

Current position: Lecturer at Tianjin Normal University, Tianjin

Thesis title: Intra- and Intersegmental Coordination among Central Pattern Generating Networks in an Insect Walking System.
TAC: Büschges/Wellmann/von Twickel, Thesis defence 13.06.2018

Publications
Central Pattern Generating Networks in Insect Locomotion.
Mantziaris C, Bockemühl T, Büschges A.
Dev Neurobiol. 2020 Jan; 80(1-2):16-30.
REVIEW

Unravelling intra- and intersegmental neuronal connectivity between central pattern generating networks in a multi-legged locomotor system.
Daun S, Mantziaris C, Tóth T, Büschges A, Rosjat N.
PLOS One Aug 2019; 14 (8): e0220767

Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect.
Goldammer J, Mantziaris C, Büschges A, Schmidt J.
PLoS One 2018 Aug 24;13(8):e0202822.

Intra- and intersegmental influences among central pattern generating networls in the walking system of the stick insect.
Mantziaris C, Bockemühl T, Holmes P, Borgmann A, Daun S, Büschges A.
J Neurophysiol, 2017; 118 (4): 2296

Current position: Scientific Coordinator of CRC TRR 341, University of Cologne

 Thesis title: Unravelling the mechanism of axonal degeneration in Hereditary Spastic Paraplegia type 7

TAC: Rugarli/Kononenko/Pasparakis, Thesis defence 19.10.2022

SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency
Montoro-Gàmez C, Nolte H, Molinié T, Evangelista G, Tröder S, Barth E, Popovic M, Trifunovic A, Zevnik B, Langer T, Rugarli EI.
Brain 2023, Apr 22; awad136. doi: 10.1093/brain/awad136. Online ahead of print.

Thesis Title: Development of Antisense Oligonucleotide Combinatorial Therapies for Spinal Muscular Atrophy (SMA)

TAC: Wirth/Rugarli/Kononenko Thesis defence 24.02.2023

Publications
SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration Fortuna TR, Kour S, Venkatakrishnan Chimata A, Muiños-Bühl A, Anderson EN, Nelson Iv, Ward C, Chauhan O, O'Brien C, Rajasundaram D, Rajan DS, Wirth B, Singh A, Pandey UB.
Acta Neuropathol. 2023 Sep;146(3):477-498.

Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects
Muiños-Bühl A, Rombo R, Ling KK, Zilio E, Rigo F, Bennett CF, Wirth B
Int J Mol Sci 2023, Feb; 24(4):4198

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
Muinos-Bühl A, Rombo R, Janzen E, Ling KK, Hupperich K, Rigo F, Bennett CF, Wirth B.
Neurobiol Dis., 2022; Jun 17:105795. Online ahead of print.

Current position: Global Product Manager Neuroscience
                               at Miltenyi Biotec

Thesis title: The role of astrocytes in neurological phenotypes associated with deficiency of the m-AAA protease
TAC: Rugarli/Wirth/Bergami, Thesis defence 19.11.2018

Publications
Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration.
Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI.
Glia 2019 Aug; 67 (8):1526

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.
Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI.
PLOS Genet, 2016 Dec 2;12(12):e1006463

Current position: Publishing Development Specialist, Frontiers, Wassen

Research associate
Research project: Functional role of the ventral tegmental area neurons in encoding of natural rewards
Advisors: Korotkova/Brüning/Steculorum

Publications
PNOC^ARC neurons promote hyperphagia and obesity upon high-fat-diet feeding.
Jais A, Paeger L, Sotelo-Hitschfelld H, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC.
Neuron, 2020; 106 (6): 1009.

Current position: PhD candidate at Kohl lab, Francis Crick Institute, London

Thesis title: Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
TAC: Kononenko/Rugarli/Wirth, Thesis defence 19.09.2019

AP-2 Reduces Amyloidogenesis by Promoting BACE1 Trafficking and Degradation in Neurons
Bera S, Camblor-Perujo S, Calleja Barca E, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, Kononenko NL.
EMBO Rep., 2020 Jun 4;21(6): e47954.

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons
Negrete-Hurtado A*, Overhoff M*, Bera S*, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko NL.
Nat Commun. 2020 Mar 24; 11 (1): 1535.
*These authors contributed equally to this work.

Current position: Regulatory Affairs Scientist, ÅKRN Scientific Consulting, Madrid

Thesis title: Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signalling
TAC: Kononenko/Wirth/Isbrandt
Thesis defence 31.03.2022

Publications:

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, Ickert L, Mohammadi M, De Bruyckere E, Kallergi E, Delle Vode A, Nikoletopoulou V, Wirth B, Isensee J, Hucho T, Puchkov D, Isbrandt D, Krueger M, Kloppenburg P, Kononenko NL.
EMBO J. 2022, Nov 17;41(22):e110963.

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons.
Negrete-Hurtado A*, Overhoff M*, Bera S*, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko NL.
Nat Commun. 2020 Mar 24; 11 (1): 1535.
*These authors contributed equally to this work.

Current position: Postdoctoral Researcher at Kononenko Lab, University Clinic Cologne, CECAD

Research stay
Research Project: Sodium activated Potassium currents in Cockroach antennal neurons
Advisors: Kloppenburg/Korsching/Nawrot

Current position: Fraunhofer Institute for Cell Therapy and Immunology (IZI), Branch Bioanalytics and Bioprocesses (IZI-BB), Potsdam

Thesis title: Role of mitochondria in neurons and astrocytes for the regulation of systemic metabolism.
TAC: Brüning/Kloppenburg/Bergami Thesis defence 07.06.2022

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.
Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S, Brüning JC
Nat Communications, 2023 Nov; 14: 7824.

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Sotelo-Hitschfeld T, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH and Brüning JC.
Nature Metabolism, 2022 Oct; 4(10):1402

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Timper K*, Del Río Martín A*, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC.
Cell Metabolism. 2020 May 15; S1550-4131(20).
*These authors contributed equally to this work.

Thesis title: NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.
TAC: Brüning/Kloppenburg/Hammerschmidt, Thesis defence 02.12.2019

Publications
NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.
Engströöm Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC.
Nat. Commun. 2020 Jan 23; 11(1): 442.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin- Growth Hormone Circuit.
Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg B, Brüning JC, Hammerschmidt M.
Cell Rep. 2018 May 8; 23(6):1728.

The Sense of Smell Impacts Metabolic Health and Obesity.
Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.
Cell Metab, 2017; 26(1): 198

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance.
Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.
Nat Commun, 2017; 8: 14803

Current position: Research Scientist at Boehringer Ingelheim, Biberach

Thesis title: Differential Modulation of POMC Neuron Subtypes by Temperature and Energy State Dependent Signals
TAC: Kloppenburg/Brüning/Wellmann, Thesis defence 26.11.2020

Publications
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT and Brüning JC.
Nature Neuroscience, 2021 Jul; 24(7): 913-929

Current position: Postdoctoral Researcher at Kloppenburg Lab, University of Cologne, Cologne

Thesis title: Characterization of the neuronal networks mediating the effects of energy homeostasis control systems on locomotion in the zebrafish
TAC: Hammerschmidt/Büschges/Odermatt, Thesis defence 26.03.2019

Publications
Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits
Reinoß P, Ciglieri E, Minère M, Bremser S, Klein A, Löhr H, Fuller PM, Büschges A, Kloppenburg P, Fenselau H, Hammerschmidt M.
Curr Biol. 2020 Dec 7; 30(23): 4579-4593.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin- Growth Hormone Circuit.
Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg B, Brüning JC, Hammerschmidt M.
Cell Rep. 2018 May 8; 23(6):1728.
 

Current position: Database and Systems Development at Henkel, Düsseldorf

Thesis title: Ionic currents and intrinsic properties of key interneurons and their influence on network activity in a chain of coupled oscillators
TAC: Wellmann/Daun/Büschges, Thesis defence 03.09.2018

Current position: Scientific Education Manager, Novartis, Cologne – Bonn area

Thesis title: Identification and Characterization of Spinal Muscular Atrophy (SMA) Modifiers - Insights from Cellular and Vertebrate Disease Models
TAC: Wirth/Kloppenburg/Hoppe, Thesis defence 11.12.2017

Publications

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL, Wirth B.
Front Mol Neurosci 2019 Feb 12; 12: 19

NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B.
Am J Human Genet 2019 Jul; 105 (1): 221

CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity end endocytosis.
Janzen E, Mendoza-Fereirra N, Hosseinibarkooie S, Schneider S, Hupperich K, Tschanz T, Grysko V, Riessland M, Hammerschmidt M, Rigo F, Bennett CF, Kye MJ, Torres-Benito L, Wirth B.
Brain. 2018 Jun 28; 141(8): 2343.

Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function.
Mendoza-Fereirra N, Coutelier M, Janzen E, Hosseinibarkooie S, Löhr H, Schneider S, Milbradt J, Karakaya M, Riessland M, Pichlo C, Torres-Benito L, Singleton A, Zuchner S, Brice A, Durr A, Hammerschmidt M, Stevanin G, Wirth B.
Neurol Genet. 2018 Jan 19; 4(1): e209.

Advances in understanding the role of disease associated proteins in spinal muscular atrophy.
Hosseinibarkooie S, Schneider S, Wirth B.
Expert Rev Proteomics, 2017; 14 (7): 581
REVIEW

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Riessland M*, Kaczmarek A*, Schneider S*, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.
*These authors contributed equally to this work.
Am J Hum Genet. 2017 Feb 2;100(2):297-315.

Investigational therapies for the treatment of spinal muscular atrophy.
Kaczmarek A*, Schneider S*, Wirth B, Riessland M.
*These authors contributed equally to this work.
Expert Opin Invest Drugs 2015;24(7):867-881
REVIEW

Current position: Advisor for Biomedicine, Fritz Thyssen Foundation, Cologne

Thesis title: Neural Networks linking crypt cells to innate attractive behavior
TAC: Korsching/Kloppenburg/Kurian, Thesis defence 12.08.2020

Thesis title: Neurocalcin delta (NCALD) knockout impairs adult neurogenesis whereas half reduction is a safe therapeutic option for spinal muscular atrophy
TAC: Wirth/Hammerschmidt/Kononenko, Thesis defence 30.11.2018

Publications
NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B.
Am J Human Genet 2019 Jul; 105 (1): 221

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL, Wirth B.
Front Mol Neurosci 2019 Feb 12; 12: 19

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Riessland M*, Kaczmarek A*, Schneider S*, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.
*These authors contributed equally to this work.
Am J Hum Genet. 2017 Feb 2;100(2):297-315.

Current position: Freelance Scientific Writer, Basel

Thesis title: Activity regulating signals in neurons associated with energy homeostasis
TAC: Kloppenburg/Brüning/Nawrot
Thesis defence: 13.02.2023

Publications:

CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake.
Vivot K, Meszaros G, Pangou E, Zhang Z, Qu M, Erbs E, Yeghiazaryan G, Quiñones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Berditchevski F, Sumara I, Luquet S, Kloppenburg P, Nogueiras R, Ricci R.
Nat Metab 2023 Jun;5(6):1045-1058. doi: 10.1038/s42255-023-00814-x

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
Xiao X, Yeghiazaryan G,  Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich TF, Rahmuni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC.
Nat Commun, 2021; 12: 5249

Current position: Postdoctoral Researcher at Kloppenburg lab, Institute of Zoology, University of Cologne

TAC: Daun/Fink/Grefkes, Thesis defence 05.02.2018

Publications

A response-locking protocol to boost sensitivity for fMRI-based neurochronometry.
Viswanathan S, Abdollahi RO, Wang BA, Grefkes C, Fink GR, Daun S.
Hum Brain Mapp, 2020 Aug 15; 41(12): 3420

Freely chosen and instructed actions are terminated by different neural mechanisms revealed by kinematics-informed EEG
Viswanathan S*, Wang BA*, Abdollahi RO, Daun S, Grefkes C, Fink GR.
Neuroimage 2018 Dec 3; 188:26
*These authors contributed equally to this work.

Aging-associated changes of moving-related functional connectivity in the human brain.
Rosjat N, Liu L, Wang BA, Popovych S, Toth T, Viswanathan S, Grefkes C, Fink GR, Daun S.
Neuropsychologia. 2018 Jul 9; S0028-3932(18)30306-3.

Age-related changes in oscillatory power affect motor action.
Liu L, Rosjat N, Popovych S, Wang BA, Yeldesbay A, Thot TI, Viswanathan S, Grefkes CB, Fink GR, Daun S.
PLoS One, 2017; 12 (11):e0187911.

Frequency-specific modulation of connectivity in the ipsilateral sensorimotor cortex by different forms of the movement initiation.
Wang BA, Viswanathan S, Abdollahi RO, Rosjat N, Popovych S, Daun S, Grefkes C, Fink GR.
Neuroimage, 2017; 159: 248.

Movement-related phase locking in the delta-theta frequency band.
Popovych S, Rosjat N, Toth TI, Wang BA, Liu L, Abdollahi RO, Viswanathan S, Grefkes C, Fink, GR, Daun S.
Neuroimage, 2016 Jun 29;139:439-449.
 

Current position: Postdoctoral Researcher at Tegenthoff lab, Ruhr Universität Bochum