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publications: core projects

A realistic locomotery model of Drosophila larva for behavioral simulations
Sakagiannis P, Jürgensen A.M., Nawrot MP.
preprint bioRxiv, doi:

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT and Brüning JC.
Nature Neuroscience, 2021 May 17, Online ahead of print

Distributed processing of load and movement feedback in the premotor network controlling an insect leg joint
Gebehart C, Schmidt J, Büschges A.
J Neurophysiol. 2021 May; 1;125(5):1800-1813.

Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
Dieris M, Kowatschew D, Korsching SI.
Sci Rep. 2021 Apr; 8;11(1):7807.

Neuromodulation can be simple: myoinhibitory peptide, contained in dedicated regulatory pathways, is the only neurally-mediated peptide modulator of the stick insect leg muscle
Liessem S, Kowatschew D, Dippel S, Blanke A, Korsching S, Guschlbauer C, Hooper SL, Predel R, Büschges A.
J Neurosci. 2021 Feb 2; JN-RM-0188-20.


publications: further collaborative projects

Transcriptomic, peptidomic, and mass spectrometry imaging analysis of the brain in the ant Cataglyphis nodus
Habenstein J, Schmitt F,  Liessem S, Ly A, Trede D, Wegener C, Predel R, Rössler W, Neupert S.

J Neurochem, 2021 Mar 11. doi: 10.1111/jnc.15346. Online ahead of print.



publications: core projects

Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits
Reinoß P, Ciglieri E, Minère M, Bremser S, Klein A, Löhr H, Fuller PM, Büschges A, Kloppenburg P, Fenselau H, Hammerschmidt M.
Curr Biol. 2020 Sep 24; "online ahead of print".

Location and arrangement of campaniform sensilla in Drosophila melanogaster
Dinges GF, Chockley AS, Bockemühl T, Ito K, Blanke A, Büschges A.
J Comp Neurol 2020 Jul 17; "online ahead of print".

A plausible mechanism for Drosophila larva intermittent behavior
Sakagiannis P, Aguilera M, Nawrot MP.
Living Machines 2020, Conference Paper

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Timper K*, Del Río Martín A*, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC.
Cell Metabolism. 2020 May 15; S1550-4131(20).
*These authors contributed equally to this work.

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons.
Negrete-Hurtado A*, Overhoff M*, Bera S*, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko NL.
Nat Commun. 2020 Mar 24; 11 (1): 1535.
*These authors contributed equally to this work.

Central Pattern Generating Networks in Insect Locomotion.
Mantziaris C, Bockemühl T, Büschges A.
Dev Neurobiol. 2020 Mar 3; Epub ahead of print.

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.
Engströöm Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC.
Nat. Commun. 2020 Jan 23; 11(1): 442.

Cockroaches Show Individuality in Learning and Memory During Classical and Operant Conditioning.
Arican C, Bulk J, Deisig N, Nawrot MP.
Front. Physiol. 2020 Jan 8; 10: 1539.

publications: further collaborative projects

Gradients in mechanotransduction of force and body weight in insects
Harris CM, Dinges GF, Haberkorn A, Gebehart C, Büschges A, Zill S.
Arthropod Stuct Dev, Sept 2020; 58 100970

A response-locking protocol to boost sensitivity for fMRI-based neurochronometry.
Viswanathan S, Abdollahi RO, Wang BA, Grefkes C, Fink GR, Daun S.
Hum Brain Mapp, 2020 Aug 15; 41(12): 3420

PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding.
Jais A, Paeger L, Sotelo-Hitschfelld H, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC.
Neuron, 2020; 106 (6): 1009.

Prefrontal-subthalamic pathway supports action selection in a spacial working memory task
Heikenfeld C, Mederos S, Chen C, Korotkova T, Schnitzler A, Ponomarenko A.
Sci Rep., 2020; 10: 10497.

AP-2 Reduces Amyloidogenesis by Promoting BACE1 Trafficking and Degradation in Neurons
Bera S, Camblor-Perujo S, Calleja Barca E, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, Kononenko NL.
EMBO Rep., 2020 Apr 23;e47954. (published ahead of print)



publications: core projects

Level of education mitigates the impact of tau pathology on neuronal function.
Hoenig MC, Bischof GN, Onur ÖA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T, Alzheimer's Disease Neuroimaging Initiative.
Eur J Nucl Med Mol Imaging. 2019 Aug; 46 (9):1787

Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration.
Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI.
Glia 2019 Aug; 67 (8):1526

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL, Wirth B.
Front Mol Neurosci 2019 Feb 12; 12: 19

publications: further collaborative projects

Unravelling intra- and intersegmental neuronal connectivity between central pattern generating networks in a multi-legged locomotor system.
Daun S, Mantziaris C, Tóth T, Büschges A, Rosjat N.
PLOS One Aug; 14 (8): e0220767

NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B.
Am J Human Genet 2019 Jul; 105 (1): 221

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.
Ruud J, Alber J, Tokarska A,  Engstöm Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC.
Cell Rep 2019 Jun 11; 27 (11): 3182

Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control.
Hammes J, Theis H, Giehl K, Hoenig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T.
Brain 2019 Mar 1; 142 (3): 733

Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass Spectrometry Imaging Protocol
Ly A, Ragionieri L, Liessem S,  Becker M, Deininger SO, Neupert S, Predel R.
Anal Chem 2019 Feb 5; 91 (3): 1980



publications: core projects

Freely chosen and instructed actions are terminated by different neural mechanisms revealed by kinematics-informed EEG
Viswanathan S*, Wang BA*, Abdollahi RO, Daun S, Grefkes C, Fink GR.
Neuroimage 2018 Dec 3; 188:26
*These authors contributed equally to this work.

Statistic stability predicts the continuum of interleg coordination patterins in Drosophila
Szczecinski NC, Bockemühl T, Chockley AS, Büschges A.
J Exp Biol 2018 Nov 16; 221: jeb189142

Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect.
Goldammer J, Mantziaris C, Büschges A, Schmidt J.
PLoS One 2018 Aug 24;13(8):e0202822.

Transcriptomic and Neuropeptidomic Analysis of the Stick Insect, Carausius morosus.
Liessem S, Ragioneri L, Neupert S, Büschges A, Predel  R.
J Proteome Res 2018, Jun 1; 17(6): 2192

Networks auf tau distribution in Alzheimer's disease.
Hoenig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur ÖA, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A.
Brain, awx353,

publications: further collaborative projects

Aging-associated changes of moving-related functional connectivity in the human brain.
Rosjat N, Liu L, Wang BA, Popovych S, Toth T, Viswanathan S, Grefkes C, Fink GR, Daun S.
Neuropsychologia. 2018 Jul 9; S0028-3932(18)30306-3.

CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity end endocytosis.
Janzen E, Mendoza-Fereirra N, Hosseinibarkooie S, Schneider S, Hupperich K, Tschanz T, Grysko V, Riessland M, Hammerschmidt M, Rigo F, Bennett CF, Kye MJ, Torres-Benito L, Wirth B.
Brain. 2018 Jun 28; 141(8): 2343.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin- Growth Hormone Circuit.
Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg B, Brüning JC, Hammerschmidt M.
Cell Rep. 2018 May 8; 23(6):1728.

Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function.
Mendoza-Fereirra N, Coutelier M, Janzen E, Hosseinibarkooie S, Löhr H, Schneider S, Milbradt J, Karakaya M, Riessland M, Pichlo C, Torres-Benito L, Singleton A, Zuchner S, Brice A, Durr A, Hammerschmidt M, Stevanin G, Wirth B.
Neurol Genet. 2018 Jan 19; 4(1):e209.



publications: core projects

Age-related changes in oscillatory power affect motor action.
Liu L, Rosjat N, Popovych S, Wang BA, Yeldesbay A, Thot TI, Viswanathan S, Grefkes CB, Fink GR, Daun S.
PLoS One, 2017; 12 (11):e0187911.

Frequency-specific modulation of connectivity in the ipsilateral sensorimotor cortex by different forms of the movement initiation.
Wang BA, Viswanathan S, Abdollahi RO, Rosjat N, Popovych S, Daun S, Grefkes C, Fink GR.
Neuroimage, 2017; 159: 248.

Intra- and intersegmental influences among central pattern generating networls in the walking system of the stick insect.
Mantziaris C, Bockemühl T, Holmes P, Borgmann A, Daun S, Büschges A.
J Neurophysiol, 2017; 118 (4): 2296

Advances in understanding the role of disease associated proteins in spinal muscular atrophy.
Hosseinibarkooie S, Schneider S, Wirth B.
Expert Rev Proteomics, 2017; 14 (7): 581

Tau pathology and cognitive reserve in Alzheimer's disease.
Hönig MC, Bischof GN, Hammes J, Faber J, Fliessbach K, van Eimeren T, Drzezga A.
Neuro Biol Aging, 2017; 57: 1

A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.
Dieris M, Ahuja G, Krishna V, Korsching S.
Sci Rep, 2017; 7: 40892

The below article received 3 stars of recommendation by the F1000:
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Riessland M*, Kaczmarek A*, Schneider S*, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.
*These authors contributed equally to this work.
Am J Hum Genet. 2017 Feb 2;100(2):297-315.

At the ESHG Conference 2017 in Copenhagen, Denmark the European Society of Human Genetics conferred the Vienna Medical Academy Award 2017 for the best talk in Translational Medicine to Svenja Schneider.

publications: further collaborative projects

The Sense of Smell Impacts Metabolic Health and Obesity.
Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.
Cell Metab, 2017; 26(1): 198

The CApillary FEeder Assay Measures Food Intake in Drosophila melanogaster.
Diegelmann S, Jansen A, Jois S, Kastenholz K, Velo Escarcena L, Strudthoff N, Scholz H.
J Vis Exp, 2017 Mar 17; 121

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance.
Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.
Nat Commun, 2017; 8: 14803



publications: further collaborative projects

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.
Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI.
PLOS Genet, 2016 Dec 2;12(12):e1006463

Movement-related phase locking in the delta-theta frequency band.
Popovych S, Rosjat N, Toth TI, Wang BA, Liu L, Abdollahi RO, Viswanathan S, Grefkes C, Fink, GR, Daun S.
Neuroimage, 2016 Jun 29;139:439-449.



publications: core projects

Investigational therapies for the treatment of spinal muscular atrophy.
Kaczmarek A*, Schneider S*, Wirth B, Riessland M.
*These authors contributed equally to this work.
Expert Opin Invest Drugs 2015;24(7):867-881