Publications

Publications of Doctoral Candidates of the RTG-NCA

2023

publications: core projects

Minimal circuit motifs for second-order conditioning in the insect mushroom body
Jürgensen AM, Schmitt FJ, Rössler W, Strube-Bloss MF, Nawrot MP.
bioRxiv, preprint, https://doi.org/10.1101/2023.09.11.557174

The mushroom body output encodes behavioral decision during sensory-motor transformation
Arican C, Schmitt FJ, Rössler W, Strube-Bloss MF, Nawrot MP.
Curr Biol 2023, Aug 2; awad136. doi: 10.1093/brain/awad136. Online ahead of print.

SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency
Montoro-Gàmez C, Nolte H, Molinié T, Evangelista G, Tröder S, Barth E, Popovic M, Trifunovic A, Zevnik B, Langer T, Rugarli EI.
Brain 2023, Apr 22; awad136. doi: 10.1093/brain/awad136. Online ahead of print.

Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects
Muiños-Bühl A, Rombo R, Ling KK, Zilio E, Rigo F, Bennett CF, Wirth B
Int J Mol Sci 2023, Feb; 24(4):4198

Efficient parameter calibration and real-time simulation of large-scale spiking neural networks with GeNN and NEST
Schmitt FJ , Rostami V, Nawrot MP
Front Neuroinform Feb 2023; 941696

publications: further collaborative projects

Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Givalisco P, Brüning JC.
Cell Metabolism, 2023 May 2; 35(5):786

Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs
Petzold A, van den Munhof HE, Figge-Schlensok R, Korotkova T
Cell Metabolism, 2023 Mar 7; 35(3):456

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2022

publications: core projects

Subsets of leg proprioceptors influence leg kinematics but not interleg coordination in Drosophila melanogaster walking
Chockley AS, Dinges GF, Di Cristina G, Ratican S, Bockemühl T, Büschges A.
J Exp Biol 2022 Oct 21;jeb.244245. Online ahead of print.

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, Ickert L, Mohammadi M, De Bruyckere E, Kallergi E, Delle Vode A, Nikoletopoulou V, Wirth B, Isensee J, Hucho T, Puchkov D, Isbrandt D, Krueger M, Kloppenburg P, Kononenko NL.
EMBO J. 2022, Oct 11;e110963. Online ahead of print.

Non-linear multimodal integration in a distributed premotor network controls proprioceptive reflex gain in the insect leg.
Gebehart C, Hooper S, Büschges A.
Current Biol. 2022, Vol 32, Issue 17, Sept 12, p. 3847

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
Muinos-Bühl A, Rombo R, Janzen E, Ling KK, Hupperich K, Rigo F, Bennett CF, Wirth B.
Neurobiol Dis., 2022; Jun 17:105795. Online ahead of print.

Ultra high-resolution biomechanics suggest that substructures within insect mechanosensors decisively affect their sensitivity
Dinges GF, Bockemühl T, Iacoviello F, Shearing PR, Büschges A, Blanke A.
J R Soc Interface, 2022; May; 19(190): 20220102

publications: further collaborative projects

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Sotelo-Hitschfeld T, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH and Brüning JC.
Nature Metabolism, 2022 Oct; 4(10):1402

Leptin modulates oocyte maturation by a central and direct pathway in zebrafish
Lakshminarasimha AB, Puvvada M, Hammerschmidt H, Michel M.
J Endocrinol, 2022; Apr 1: JOE-22-0026, Online ahead of print.

Network analysis of neuroimaging in mice.
Scharwächter L, Schmitt FJ, Pallast N, Fink GR, Aswendt M.
NeuroImage, 2022; 253: 119110 Online ahead of print.
REVIEW

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2021

publications: core projects

Temporal differences between load and movement signal integration in the sensorimotor network of an insect leg.
Gebehart C, Büschges A.
J Neurophysiol. 2021 Dec; 1;126(6):1875-18903.

**** WITH PODCAST FEATURE ****
Coauthors Corinna Gebehart and Ansgar Büschges talk about their manuscript "Temporal Differences between Load and Movement Signal Integration in the Sensorimotor Network of an Insect Leg"
with Editor-in-Chief Jan-Marino (Nino) Ramirez.
To access the podcast, click HERE

A neuromorphic model of olfactory processing and sparse coding in the Drosophila larva brain.
Jürgensen AM, Khalili A, Chicca E, Indiveri G, Nawrot MP.
accepted manuscript, Neuromorph Comput Eng
https://doi.org/10.1088/2634-4386/ac3ba6

A realistic locomotery model of Drosophila larva for behavioral simulations
Sakagiannis P, Jürgensen A.M., Nawrot MP.
preprint bioRxiv, doi: https://doi.org/10.1101/2021.07.07.451470

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT and Brüning JC.
Nature Neuroscience, 2021 Jul; 24(7):913

Distributed processing of load and movement feedback in the premotor network controlling an insect leg joint
Gebehart C, Schmidt J, Büschges A.
J Neurophysiol. 2021 May; 1;125(5):1800-1813.

**** WITH PODCAST FEATURE ****
In this podcast, senior author Ansgar Buschges and first author Corinna Gebehart address these questions with Editor-in-Chief Nino Ramirez to their manuscript,"Distributed Processing of Load and Movement Feedback in the Premotor Network Controlling an Insect Leg Joint.".
To access the podcast, click HERE

Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently
Dieris M, Kowatschew D, Korsching SI.
Sci Rep. 2021 Apr; 8;11(1):7807.

Location and arrangement of campaniform sensilla in Drosophila melanogaster
Dinges GF, Chockley AS, Bockemühl T, Ito K, Blanke A, Büschges A.
J Comp Neurol 2021 Mar;529(4):905.

Neuromodulation can be simple: myoinhibitory peptide, contained in dedicated regulatory pathways, is the only neurally-mediated peptide modulator of the stick insect leg muscle
Liessem S, Kowatschew D, Dippel S, Blanke A, Korsching S, Guschlbauer C, Hooper SL, Predel R, Büschges A.
J Neurosci. 2021 Feb 2; JN-RM-0188-20.

publications: further collaborative projects

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich TF, Rahmuni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC.
Nat Commun, 2021; 12: 5249

Transcriptomic, peptidomic, and mass spectrometry imaging analysis of the brain in the ant Cataglyphis nodus
Habenstein J, Schmitt F, Liessem S, Ly A, Trede D, Wegener C, Predel R, Rössler W, Neupert S.
J Neurochem, 2021 Jul; 158(2): 391

2020

publications: core projects

Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits
Reinoß P, Ciglieri E, Minère M, Bremser S, Klein A, Löhr H, Fuller PM, Büschges A, Kloppenburg P, Fenselau H, Hammerschmidt M.
Curr Biol. 2020 Dec 7; 30(23): 4579

A plausible mechanism for Drosophila larva intermittent behavior
Sakagiannis P, Aguilera M, Nawrot MP.
Living Machines 2020, Conference Paper

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Timper K*, Del Río Martín A*, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC.
Cell Metabolism. 2020 May 15; S1550-4131(20).
*These authors contributed equally to this work.

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons.
Negrete-Hurtado A*, Overhoff M*, Bera S*, De Bruyckere E, Schätzmüller K, Kye MJ, Qin C, Lammers M, Kondylis V, Neundorf I, Kononenko NL.
Nat Commun. 2020 Mar 24; 11 (1): 1535.
*These authors contributed equally to this work.

Central Pattern Generating Networks in Insect Locomotion.
Mantziaris C, Bockemühl T, Büschges A.
Dev Neurobiol. 2020 Jan; 80 (1-2): 16
REVIEW

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.
Engströöm Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC.
Nat. Commun. 2020 Jan 23; 11(1): 442.

Cockroaches Show Individuality in Learning and Memory During Classical and Operant Conditioning.
Arican C, Bulk J, Deisig N, Nawrot MP.
Front. Physiol. 2020 Jan 8; 10: 1539.

publications: further collaborative projects

Gradients in mechanotransduction of force and body weight in insects
Harris CM, Dinges GF, Haberkorn A, Gebehart C, Büschges A, Zill S.
Arthropod Stuct Dev, Sept 2020; 58 100970

A response-locking protocol to boost sensitivity for fMRI-based neurochronometry.
Viswanathan S, Abdollahi RO, Wang BA, Grefkes C, Fink GR, Daun S.
Hum Brain Mapp, 2020 Aug 15; 41(12): 3420

PNOC^ARC neurons promote hyperphagia and obesity upon high-fat-diet feeding.
Jais A, Paeger L, Sotelo-Hitschfelld H, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC.
Neuron, 2020; 106 (6): 1009.

Prefrontal-subthalamic pathway supports action selection in a spacial working memory task
Heikenfeld C, Mederos S, Chen C, Korotkova T, Schnitzler A, Ponomarenko A.
Sci Rep., 2020; 10: 10497.

AP-2 Reduces Amyloidogenesis by Promoting BACE1 Trafficking and Degradation in Neurons
Bera S, Camblor-Perujo S, Calleja Barca E, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, Kononenko NL.
EMBO Rep., 2020 Apr 23;e47954.

2019

publications: core projects

Level of education mitigates the impact of tau pathology on neuronal function.
Hoenig MC, Bischof GN, Onur ÖA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T, Alzheimer's Disease Neuroimaging Initiative.
Eur J Nucl Med Mol Imaging. 2019 Aug; 46 (9):1787

Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration.
Murru S, Hess S, Barth E, Almajan ER, Schatton D, Hermans S, Brodesser S, Langer T, Kloppenburg P, Rugarli EI.
Glia 2019 Aug; 67 (8):1526

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres-Benito L, Mendoza-Ferreira N, Overhoff M, Rombo R, Grysko V, Kye MJ, Kononenko NL, Wirth B.
Front Mol Neurosci 2019 Feb 12; 12: 19

publications: further collaborative projects

Unravelling intra- and intersegmental neuronal connectivity between central pattern generating networks in a multi-legged locomotor system.
Daun S, Mantziaris C, Tóth T, Büschges A, Rosjat N.
PLOS One Aug; 14 (8): e0220767

NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B.
Am J Human Genet 2019 Jul; 105 (1): 221

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.
Ruud J, Alber J, Tokarska A, Engstöm Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC.
Cell Rep 2019 Jun 11; 27 (11): 3182

Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control.
Hammes J, Theis H, Giehl K, Hoenig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T.
Brain 2019 Mar 1; 142 (3): 733

Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass Spectrometry Imaging Protocol
Ly A, Ragionieri L, Liessem S, Becker M, Deininger SO, Neupert S, Predel R.
Anal Chem 2019 Feb 5; 91 (3): 1980

2018

publications: core projects

Freely chosen and instructed actions are terminated by different neural mechanisms revealed by kinematics-informed EEG
Viswanathan S*, Wang BA*, Abdollahi RO, Daun S, Grefkes C, Fink GR.
Neuroimage 2018 Dec 3; 188:26
*These authors contributed equally to this work.

Statistic stability predicts the continuum of interleg coordination patterins in Drosophila
Szczecinski NC, Bockemühl T, Chockley AS, Büschges A.
J Exp Biol 2018 Nov 16; 221: jeb189142

Calcium imaging of CPG-evoked activity in efferent neurons of the stick insect.
Goldammer J, Mantziaris C, Büschges A, Schmidt J.
PLoS One 2018 Aug 24;13(8):e0202822.

Transcriptomic and Neuropeptidomic Analysis of the Stick Insect, Carausius morosus.
Liessem S, Ragioneri L, Neupert S, Büschges A, Predel R.
J Proteome Res 2018, Jun 1; 17(6): 2192

Networks auf tau distribution in Alzheimer's disease.
Hoenig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur ÖA, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A.
Brain, awx353, https://doi.org/10.1093/brain/awx353.

publications: further collaborative projects

Aging-associated changes of moving-related functional connectivity in the human brain.
Rosjat N, Liu L, Wang BA, Popovych S, Toth T, Viswanathan S, Grefkes C, Fink GR, Daun S.
Neuropsychologia. 2018 Jul 9; S0028-3932(18)30306-3.

CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity end endocytosis.
Janzen E, Mendoza-Fereirra N, Hosseinibarkooie S, Schneider S, Hupperich K, Tschanz T, Grysko V, Riessland M, Hammerschmidt M, Rigo F, Bennett CF, Kye MJ, Torres-Benito L, Wirth B.
Brain. 2018 Jun 28; 141(8): 2343.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin- Growth Hormone Circuit.
Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg B, Brüning JC, Hammerschmidt M.
Cell Rep. 2018 May 8; 23(6):1728.

Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function.
Mendoza-Fereirra N, Coutelier M, Janzen E, Hosseinibarkooie S, Löhr H, Schneider S, Milbradt J, Karakaya M, Riessland M, Pichlo C, Torres-Benito L, Singleton A, Zuchner S, Brice A, Durr A, Hammerschmidt M, Stevanin G, Wirth B.
Neurol Genet. 2018 Jan 19; 4(1):e209.

2017

publications: core projects

Age-related changes in oscillatory power affect motor action.
Liu L, Rosjat N, Popovych S, Wang BA, Yeldesbay A, Thot TI, Viswanathan S, Grefkes CB, Fink GR, Daun S.
PLoS One, 2017; 12 (11):e0187911.

Frequency-specific modulation of connectivity in the ipsilateral sensorimotor cortex by different forms of the movement initiation.
Wang BA, Viswanathan S, Abdollahi RO, Rosjat N, Popovych S, Daun S, Grefkes C, Fink GR.
Neuroimage, 2017; 159: 248.

Intra- and intersegmental influences among central pattern generating networls in the walking system of the stick insect.
Mantziaris C, Bockemühl T, Holmes P, Borgmann A, Daun S, Büschges A.
J Neurophysiol, 2017; 118 (4): 2296

Advances in understanding the role of disease associated proteins in spinal muscular atrophy.
Hosseinibarkooie S, Schneider S, Wirth B.
Expert Rev Proteomics, 2017; 14 (7): 581
REVIEW

Tau pathology and cognitive reserve in Alzheimer's disease.
Hönig MC, Bischof GN, Hammes J, Faber J, Fliessbach K, van Eimeren T, Drzezga A.
Neuro Biol Aging, 2017; 57: 1

A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.
Dieris M, Ahuja G, Krishna V, Korsching S.
Sci Rep, 2017; 7: 40892

The below article received 3 stars of recommendation by the F1000:
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.
Riessland M*, Kaczmarek A*, Schneider S*, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.
*These authors contributed equally to this work.
Am J Hum Genet. 2017 Feb 2;100(2):297-315.

At the ESHG Conference 2017 in Copenhagen, Denmark the European Society of Human Genetics conferred the Vienna Medical Academy Award 2017 for the best talk in Translational Medicine to Svenja Schneider.

publications: further collaborative projects

The Sense of Smell Impacts Metabolic Health and Obesity.
Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.
Cell Metab, 2017; 26(1): 198

The CApillary FEeder Assay Measures Food Intake in Drosophila melanogaster.
Diegelmann S, Jansen A, Jois S, Kastenholz K, Velo Escarcena L, Strudthoff N, Scholz H.
J Vis Exp, 2017 Mar 17; 121

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance.
Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.
Nat Commun, 2017; 8: 14803

2016

publications: further collaborative projects

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.
Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI.
PLOS Genet, 2016 Dec 2;12(12):e1006463

Movement-related phase locking in the delta-theta frequency band.
Popovych S, Rosjat N, Toth TI, Wang BA, Liu L, Abdollahi RO, Viswanathan S, Grefkes C, Fink, GR, Daun S.
Neuroimage, 2016 Jun 29;139:439-449.

University of Cologne

Faculty of Mathematics and Natural SciencesResearch Training Network - Neural Circuit Analysis on the Cellular and Subcellular Level

Publications of Doctoral Candidates of the RTG-NCA

2023

publications: core projects

publications: further collaborative projects

2022

publications: core projects

publications: further collaborative projects

2021

publications: core projects

publications: further collaborative projects

2020

publications: core projects

publications: further collaborative projects

2019

publications: core projects

publications: further collaborative projects

2018

publications: core projects

publications: further collaborative projects

2017

2017

publications: core projects

publications: further collaborative projects

2016

publications: further collaborative projects

2015

publications: core projects

Publications of Doctoral Candidates of the RTG-NCA

2023

publications: core projects

publications: further collaborative projects

2022

publications: core projects

publications: further collaborative projects

2021

publications: core projects

publications: further collaborative projects

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2020

2019

2018

2017

2016

2015