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Publications of Doctoral Candidates of the RTG-NCA


publications: core projects

The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioral transitions.
Chen C*, Altafi M*, Corbu M, Trenk A, Munkhof H, Weineck K, Bender F, Carus-Cadavieco M, Bakhareva A, Korotkova T, Ponomarenko A.
Nature Neurosci 2024 Mar 18. doi: 10.1038/s41593-024-01598-3. advanced online
*These authors contributed equally to this work.

The synaptic drive of central pattern-generating networks to leg motor neurons of a walking insect is motor neuron pool specific
Ruthe A, Mantziaris C, Büschges A
Curr Biol, 2024, online 01 February

The processing of proprioceptive signals in distributed networks: insights from insect motor control
Gebehart C
, Büschges A.
J Exp Biol, 2024, Jan 1;227(1):jeb246182. doi: 10.1242/jeb.246182

Related content: ECR Spotllight Corinna Gebehart: J Exp Biol (2024) 227 (1): jeb247066.

More information about the ECR Spotlight series as displayed on the webiste of
J Exp Biol
"ECR Spotlight is a series of interviews with early-career authors from a selection of papers published in Journal of Experimental Biology and aims to promote not only the diversity of early-career researchers (ECRs) working in experimental biology but also the huge variety of animals and physiological systems that are essential for the ‘comparative’ approach."

Minimal circuit motifs for second-order conditioning in the insect mushroom body.
Jürgensen, A. M., Schmitt, F.J., & Nawrot, M.P.
Front. Physiol 14 (2024),



publications: core projects

Prediction error drives associative olfactory learning and conditioned behavior in a spiking model of Drosophila larva
Jürgensen AM, Sakagiannis P,
Schleyer M, Gerber B, Nawrot MP
iScience, 2023 doi: 10.1101/2022.12.21.521372

Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish
Birdal G, D' Gama PP, Jurisch-Yaksi N, Korsching SI.
Chem Senses, 2023, Vol 48, bjad040,

Minimal circuit motifs for second-order conditioning in the insect mushroom body
Jürgensen AM, Schmitt FJ, Rössler W, Strube-Bloss MF, Nawrot MP.
bioRxiv, preprint,

The mushroom body output encodes behavioral decision during sensory-motor transformation
Arican C, Schmitt FJ, Rössler W, Strube-Bloss MF, Nawrot MP.
Curr Biol, 2023 Oct 9;33(19):4217-4224.e4

Related content:
Smith and Lei contributed a commentary article to the work of
Arican C, Schmitt FJ et al, highlighting the importance and significance
of their findings:

Decision-making: A new role for insect mushroom bodies
Smith BH, Lei H
Curr Biol, 2023 Oct 9;33(19):R1004-R1006

SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency
Montoro-Gàmez C, Nolte H, Molinié T, Evangelista G, Tröder S, Barth E, Popovic M, Trifunovic A, Zevnik B, Langer T, Rugarli EI.
Brain 2023, Apr 22; awad136. doi: 10.1093/brain/awad136. Online ahead of print.

Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects
Muiños-Bühl A, Rombo R, Ling KK, Zilio E, Rigo F, Bennett CF, Wirth B
Int J Mol Sci 2023, Feb; 24(4):4198

Efficient parameter calibration and real-time simulation of large-scale spiking neural networks with GeNN and NEST
Schmitt FJ , Rostami V, Nawrot MP
Front Neuroinform Feb 2023; 941696


publications: further collaborative projects

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.
Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S,
Brüning JC
Nat Communications, 2023 Nov; 14: 7824.

SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration
Fortuna TR, Kour S, Venkatakrishnan Chimata A, Muiños-Bühl A, Anderson EN, Nelson Iv, Ward C, Chauhan O, O'Brien C, Rajasundaram D, Rajan DS, Wirth B, Singh A,
Pandey UB.
Acta Neuropathol. 2023 Sep;146(3):477-498.

CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake.
Vivot K, Meszaros G, Pangou E, Zhang Z, Qu M, Erbs E, Yeghiazaryan G, Quiñones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Berditchevski F, Sumara I, Luquet S, Kloppenburg P, Nogueiras R, Ricci R.
Nat Metab 2023 Jun;5(6):1045-1058. doi: 10.1038/s42255-023-00814-x

Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Givalisco P, Brüning JC.
Cell Metabolism, 2023 May 2; 35(5):786

Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs
Petzold A, van den Munhof HE, Figge-Schlensok R, Korotkova T
Cell Metabolism, 2023 Mar 7; 35(3):456

The Concept of Motor Reserve in Parkinson's Disease: New Wine in Old Bottles?
Hoenig MC, Dzialas V, Drzezga A, van Eimeren T
Mov Disord. 2023 Jan;38(1):16-20. doi: 10.1002/mds.29266.




publications: core projects

Subsets of leg proprioceptors influence leg kinematics but not interleg coordination in Drosophila melanogaster walking
Chockley AS, Dinges GF, Di Cristina G, Ratican S, Bockemühl T, Büschges A.
J Exp Biol 2022 Oct 21;jeb.244245. Online ahead of print.

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse
Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, Ickert L, Mohammadi M, De Bruyckere E, Kallergi E, Delle Vode A, Nikoletopoulou V, Wirth B, Isensee J, Hucho T, Puchkov D, Isbrandt D, Krueger M, Kloppenburg P, Kononenko NL.
EMBO J. 2022, Oct 11;e110963. Online ahead of print.

Non-linear multimodal integration in a distributed premotor network controls proprioceptive reflex gain in the insect leg.
Gebehart C, Hooper S, Büschges A.
Current Biol. 2022, Vol 32, Issue 17, Sept 12, p. 3847

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
Muinos-Bühl A, Rombo R, Janzen E, Ling KK, Hupperich K, Rigo F, Bennett CF, Wirth B.
Neurobiol Dis., 2022; Jun 17:105795. Online ahead of print.

Ultra high-resolution biomechanics suggest that substructures within insect mechanosensors decisively affect their sensitivity
Dinges GF, Bockemühl T, Iacoviello F, Shearing PR, Büschges A, Blanke A.
J R Soc Interface, 2022; May; 19(190): 20220102


publications: further collaborative projects

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Sotelo-Hitschfeld T, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH and Brüning JC.
Nature Metabolism, 2022 Oct; 4(10):1402

Leptin modulates oocyte maturation by a central and direct pathway in zebrafish
Lakshminarasimha AB, Puvvada M, Hammerschmidt H, Michel M.
J Endocrinol, 2022; Apr 1: JOE-22-0026, Online ahead of print.

Network analysis of neuroimaging in mice.
Scharwächter L, Schmitt FJ, Pallast N, Fink GR, Aswendt M.
NeuroImage, 2022; 253: 119110 Online ahead of print.